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[Sun Yat-sen University] Angelica is expected to prevent PM2.5 pathological changes, Sun Yat-sen University's research is international

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[Sun Yat-sen University] Angelica is expected to prevent PM2.5 pathological changes, Sun Yat-sen University's research is international

02 Dec, 2017

[Sun Yat-sen University] Angelica is expected to prevent PM2.5 pathological changes, Sun Yat-sen University's research is international

"Compendium of Materia Medica" records that "angelica" can "harmonize blood and replenish blood." The research team of Chia C. Wang, an assistant professor in the Department of Chemistry at National Sun Yat-sen University, for the first time scientifically confirmed that "the wisdom of ancestors for thousands of years is not just talking about it." She found An active ingredient in angelica, "phthalide compounds", can indeed regulate and enhance the effect of blood transporting oxygen. The research results have been published in the internationally renowned journal "Scientific Reports". It is expected to be used in the development of PM2 through animal and human experiments in the future preventive medicine.

This study was caused by Chia C. Wang sudden inspiration when she was eating "Angelica noodles". "Everyone has heard that Angelica can nourish blood and promote blood. At that time, I wanted to say that this is true?" Spiritually, when Chia C. Wang returned to the laboratory, she devoted herself to the research on the influence of angelica on the blood. She dripped the angelica extract into human blood for in vitro experimental observations. Through resonance Raman spectroscopy, blood oxygen balance experiment and protein theoretical calculation simulation, it lasted three years. Half, it was finally confirmed that an active substance in Angelica does regulate the molecular structure of hemoglobin (also known as hemoglobin), the protagonist responsible for transporting oxygen in the blood, and thereby enhance the blood's ability to release oxygen to tissue cells.

"This is the first scientific method in the world to confirm that angelica can really'tonify blood and promote blood at the molecular level." Chia C. Wang said that angelica has been used by humans for a thousand years. This study has finally confirmed that it can replenish blood functions and promote oxygen to act. Whole body organ cells. Animals, clinical trials and safety dose tests will continue to be carried out. In the future, new drugs or preventive medicines will be developed to be applied to various major diseases related to hypoxia, including cardiovascular diseases and neurodegenerative diseases of the brain (such as Aziz Haimer’s disease) and cancer.

Chia C. Wang , who is also director of the Aerosol Science Research Center of Sun Yat sen University, pointed out that according to the latest ten major causes of death in Taiwan published by the Ministry of health and welfare in June 106, up to seven diseases are related to PM2.5 exposure, and it is urgent to develop relevant prevention methods. Among the pm2.5-related diseases, chronic obstructive pulmonary disease (COPD) is easily neglected, but it ranks the third leading cause of human death in the world. Recent studies have found that increasing PM2.5 exposure by 10 μ g / m3 per day can increase the mortality rate of COPD by 2.5%. Chia C. Wang said that when the lung is blocked, the efficiency of oxygen and carbon dioxide gas exchange in the damaged alveoli will also be reduced, resulting in the inability to inhale enough oxygen to maintain the normal operation of the body. Hypoxia of cells and tissues is the inevitable result of COPD. Therefore, "finding an effective way to improve the efficiency of blood oxygen delivery and release" is one of the strategies that may help to prevent or buffer PM2.5 from causing impact or even pathological changes to organs and tissues of the whole body.

The research results on the effects of active substances in Angelica sinensis on blood function are expected to be applied to the development of PM2.5 preventive medicine in the future. The team of Aerosol Science Research Center

of Sun Yat sen University, led by Chia C. Wang, is working with domestic medical system and foreign research units to actively develop new drugs and preventive methods that can reduce various major diseases caused by PM2.5.

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The maintenance of human life depends entirely on whether there is enough oxygen that can be smoothly transported to all organs, tissues and cells of the body, so that they can normally play their due biological functions. Once cellular hypoxia occurs, it may lead to biological dysfunction and various pathological changes, or it may lead to death in a very short time due to hypoxia and asphyxia. The key protagonist responsible for oxygen delivery in the human body is hemoglobin (also known as heme).

Chia C. Wang said that hemoglobin is a built-in highly sophisticated molecular machine endowed by nature to support human life. Hemoglobin is a tetramer composed of two α - globulin monomers and two β - globulin monomers. The delivery and release of oxygen in the human body is accomplished through the synergy between the four globulin monomers and their corresponding molecular configurations. We call when inhaled, the microscopic hemoglobin molecule is also breathing. Through the conversion between two different hemoglobin configurations, including relaxed (R state) and tense (T state), hemoglobin can carry or release oxygen.

Hemoglobin can be said to be one of the first proteins that scientists began to study. As early as 1962, the molecular biologist Professor Max. Perutz was awarded the Nobel Prize in Chemistry for his first analysis of the structure of hemoglobin. But in addition to hemoglobin itself, there is also an important chemical component in the human body. 2,3-Diphosphoglycerate (2,3-BPG) plays the role of an allosteric modulator in red blood cells, which can help hemoglobin in Release oxygen to various organs and tissue cells at an appropriate time. However, as we age, the efficiency of 2,3-BPG synthesis in the human body will gradually decrease, resulting in a gradual decrease in the efficiency of hemoglobin releasing oxygen.